The CPTAC study Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma has been published in Cancer Cell. Congratulations to Chen, Sara, and all co-authors! In addition to providing more complete biological understanding of HPV-negative HNSCC, this study demonstrates the potential of proteogenomics as a therapeutic hypothesis generator. First, focused characterization of the target proteins and pathways of the standard-of-care or investigational drugs identifies biomarkers that may help match HNSCC patients to available treatments. Moreover, unbiased exploratory analysis of proteogenomic data further reveals new putative therapeutic targets for further experimental validation.
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