Xinpei’s paper caAtlas: An immunopeptidome atlas of human cancer has been published in iScience. This paper reports an immunopeptidome atlas of human cancer constructed through an extensive collection of 43 published immunopeptidomic datasets and standardized analysis of 81.6 million MS/MS spectra using Open-pFind. The study greatly expands the current knowledge of MHC-bound antigens, including an unprecedented characterization of post-translationally modified antigens. Further analysis of these data provides evidence for tumor specific-presentation of post translationally modified antigens, cancer testis antigens and cancer type-specific tumor associated antigens. All these data together with annotated MS/MS spectra supporting identification of each antigen are available in an easily browsable web portal named cancer antigen atlas (caAtlas). caAtlas provides a central resource for the selection and prioritization of MHC-bound peptides for in vitro HLA binding assay and immunogenicity testing, which will pave the way to eventual development of cancer immunotherapies. Congratulations to Xinpei, Yuxing, and all coauthors!
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