The CPTAC study Proteogenomic insights suggest druggable pathways in endometrial carcinoma has been published in Cancer Cell. Congratulations to Yongchao and all co-authors! Some of the key findings include identifying two peptides that can predict antigen processing and presentation machinery activity, revealing a potential role for metformin treatment in non-diabetic patients with elevated MYC activity, discoverying PIK3R1 in-frame indels as a primary driver of elevated AKT phosphorylation and increased sensitivity to AKT inhibitors, and connecting CTNNB1 hotspot mutations to pS45 phosphorylation-induced degradation of β-catenin.
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