The paper Pan-cancer proteogenomics expands the landscape of therapeutic targets has been published in Cell! Congratulations to co-first authors Sara, Xinpei, Jonathan, Bo, Hongwei, and Yuxing, as well as the Gao and Valentina labs for their outstanding experimental validation of the predicted targets. This study integratesClinical Proteomic Tumor Analysis Consortium (CPTAC) proteogenomics data from 1,043 patients across 10 cancer types with additional public datasets to identify potential oncology targets. These include overexpressed and hyperactivated protein dependencies, protein dependencies associated with the loss of tumor suppressor genes, and putative neoantigens and tumor-associated antigens. These analyses, summarized at https://targets.linkedomics.org, form a comprehensive landscape of protein and peptide targets for companion diagnostics, drug repurposing, and therapy development.
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