We are excited to share the publication of our latest study in Cell Reports Medicine: “A 15-layer multi-omics analysis of gastric cancer ecotypes provides therapeutic insights.” By integrating 159 primary gastric adenocarcinomas and 30 matched normal tissues across 15 molecular layers, the work uses cell-state deconvolution to define tumor ecotypes that refine established genomic subtypes and capture distinct microenvironment architectures linked to clinical outcomes and immunotherapy response. The analysis prioritizes genomic vulnerabilities, ecotype-specific pathways and metabolic programs, and microbiome features tied to resistance, offering a systems-level blueprint for gastric cancer precision oncology. Congratulations to co-first author Lindsey K. Olsen and the whole team on this outstanding collaborative effort!
Read the paper on PubMed.