Paul Shafer

A 15-layer multi-omics analysis of gastric cancer ecotypes provides therapeutic insights.

Wang Y^#, Olsen LK^#, Jiao F, Wang C, Jiang KX, Dou Y, Hu Y, Jiao L, Chen W, Elizarraras JM, Khare P, Yu N, Zhu H, Chen L, Lih TM, Eser PÖ, Rodrigues FM, Shi Z, Zhang C, Yu C, Heiman DI, Liao Y, Shafer PW, Choi S, Choi JM, Savage SR, Jaehnig EJ, Lei JT, Sun Y, Peng CW, Sun Z, Morenkov P, Zhang K, Geffen Y, Hess J, Kumar-Sinha C, Mani DR, Ding L, Getz G, Li QK, Omenn GS, Le A, Hostetter G, Newton CJ, Cai S, Ketchum KA, Robles AI, Mesri M, Minoo P, Camargo MC, An E, Hruban RH, Liu Z, Thiagarajan M, Dohlman AB, Jin RU, Huang L, Chan DW, Zhang H, Zhang B.

Cell Rep Med, 7(5):102756, 2026. (# first authors)

ZP4: A novel target for CAR-T cell therapy in triple negative breast cancer.

Somes LK, Lei JT, Yi X, Chamorro DF, Shafer P, Gad AZ, Dobrolecki LE, Madaras E, Ahmed N, Lewis MT, Zhang B, Hoyos V.

Mol Ther., 33(4):1621-1641, 2025.

Pan-cancer proteogenomics expands the landscape of therapeutic targets.

Savage SR, Yi X, Lei JT, Wen B, Zhao H, Liao Y, Jaehnig EJ, Somes LK, Shafer PW, Lee TD, Fu Z, Dou Y, Shi Z, Gao D, Hoyos V, Gao Q, Zhang B.

Cell, 187(16):4389-4407, 2024.

Incongruity between T cell receptor recognition of breast cancer hotspot mutations ESR1 Y537S and D538G following exogenous peptide loading versus endogenous antigen processing.

Shafer P, Leung WK, Woods M, Choi JM, Rodriguez-Plata CM, Maknojia A, Mosquera A, Somes LK, Joubert J, Manliguez A, Ranjan R, Burt B, Lee HS, Zhang B, Fuqua S, Rooney C, Leen AM, Hoyos V.

Cytotherapy, 26(3):266-275, 2024.